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SS-31 — 10mg

Aromatic-Cationic Tetrapeptide / Mitochondrial Origin

SS-31 (Elamipretide / MTP-131) is a synthetic aromatic-cationic tetrapeptide with 502 indexed PubMed records, spanning 219 human-related and 409 animal studies and 2 registered clinical studies.

$75.00

SS-31 (Elamipretide) is a cell-permeable tetrapeptide that selectively targets the inner mitochondrial membrane, where it binds to cardiolipin, a phospholipid critical for the electron transport chain

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SKU: LL-SS31-10 Category:

PubMed Literature Index

502

studies indexed in the public literature

Q2 2026 · view PubMed search ↗

219
Human
409
Animal
2
Clinical Trials
0
EU Trials

Overview

In the literature, SS-31 is described as a synthetic tetrapeptide built on an alternating aromatic-cationic motif (D-Arg-2',6'-dimethylTyr-Lys-Phe-NH2) that concentrates in the inner mitochondrial membrane through electrostatic attraction to its negative charge. Studies describe the peptide as remaining outside the mitochondrial matrix, instead binding cardiolipin, the signature phospholipid of the inner membrane, and altering cristae architecture. This cardiolipin interaction is proposed in the literature to restore cristae morphology and the organization of electron transport chain supercomplexes, which researchers associate with mitochondrial efficiency in experimental models.

Chemical & Molecular Properties

FormulaC32H49N9O5
Mol. Weight639.8 g/mol
PubChem CID11764719

Key Areas of Research Interest

  • Investigated in the context of inner mitochondrial membrane targeting and cardiolipin binding
  • Investigated in the context of mitochondrial cristae architecture and morphology
  • Investigated in the context of electron transport chain supercomplex organization
  • Investigated in the context of mitochondrial bioenergetic efficiency

FAQ

What is SS-31 commonly researched for?

SS-31 is studied in the research literature for its interaction with the inner mitochondrial membrane, including cardiolipin binding, cristae architecture, and electron transport chain supercomplex organization, across 502 indexed PubMed records (219 human-related, 409 animal, 2 clinical).

Is SS-31 FDA-approved?

No. Sold for laboratory research use only, not FDA-approved, not for human or veterinary consumption.

How is SS-31 stored?

Lyophilized and frozen, protected from light; refrigerated after reconstitution for research use.

What purity standard does Legendary Labz hold SS-31 to?

Every lot of SS-31 is independently third-party tested to verify identity and purity prior to release.

Is a Certificate of Analysis available for SS-31?

COAs are published per lot as testing completes.

Materials referenced on this page are intended for laboratory research purposes. No claims regarding therapeutic efficacy are made or implied. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.

Description

Overview

SS-31 (Elamipretide) is a cell-permeable tetrapeptide that selectively targets the inner mitochondrial membrane, where it binds to cardiolipin, a phospholipid critical for the electron transport chain efficiency. By protecting cardiolipin from oxidative damage, SS-31 restores ATP production in damaged or aged mitochondria. Originally developed for heart failure and acute kidney injury, it demonstrates remarkable energy restoration in aging models and neurological conditions.

Structure & Chemistry

  • Molecular formula: C₃₂H₄₉N₉O₅
  • Category: MITOCHONDRIAL / CARDIOPROTECTIVE
  • Molecular size: 640.8 Da (Tetrapeptide: D-Arg-dimethylTyr-Lys-Phe-NH2)

Regulatory & Research Status

  • FDA: Investigational drug (IND active, Stealth BioTherapeutics). Heart failure Phase 2 trials conducted (PROGRESS-HF). Not approved; available as research compound.
  • WADA: Not currently listed as prohibited.
  • Evidence: Phase 2 human data exists for heart failure and Barth syndrome. Longevity/anti-aging use extrapolated from animal models.

Specifications

Presentation 10mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category MITOCHONDRIAL / CARDIOPROTECTIVE
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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Overview

SS-31 (Elamipretide) is a cell-permeable tetrapeptide that selectively targets the inner mitochondrial membrane, where it binds to cardiolipin, a phospholipid critical for the electron transport chain efficiency. By protecting cardiolipin from oxidative damage, SS-31 restores ATP production in damaged or aged mitochondria. Originally developed for heart failure and acute kidney injury, it demonstrates remarkable energy restoration in aging models and neurological conditions.

Structure & Chemistry

  • Molecular formula: C₃₂H₄₉N₉O₅
  • Category: MITOCHONDRIAL / CARDIOPROTECTIVE
  • Molecular size: 640.8 Da (Tetrapeptide: D-Arg-dimethylTyr-Lys-Phe-NH2)

Regulatory & Research Status

  • FDA: Investigational drug (IND active, Stealth BioTherapeutics). Heart failure Phase 2 trials conducted (PROGRESS-HF). Not approved; available as research compound.
  • WADA: Not currently listed as prohibited.
  • Evidence: Phase 2 human data exists for heart failure and Barth syndrome. Longevity/anti-aging use extrapolated from animal models.

Specifications

Presentation 10mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category MITOCHONDRIAL / CARDIOPROTECTIVE
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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