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Semax

Heptapeptide / ACTH(4-10) Origin

Semax is a synthetic heptapeptide derived from the ACTH(4-10) fragment, with 229 indexed PubMed research records spanning human and animal studies.

Price range: $30.00 through $45.00

Semax is a synthetic heptapeptide derived from ACTH, developed in Russia in the 1980s and widely used there as a prescription nootropic. It dramatically upregulates BDNF

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Certificates of Analysis

Independently tested by Horizon Analytical. Tap to open the full report.

🧪Purity Report
99.34% · Lot LL-4383620-POPEN ↗🛡Endotoxin Report
Lot LL-4383620-EOPEN ↗
SKU: LL-SEMAX Category:

PubMed Literature Index

229

studies indexed in the public literature

Q2 2026 · view PubMed search ↗

50
Human
213
Animal
0
Clinical Trials
0
EU Trials

Overview

In the research literature, Semax is described as a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-10) fragment, the portion of ACTH associated with cognitive activity apart from its adrenal-stimulating action. Studies administering Semax intranasally describe it crossing the blood-brain barrier via the olfactory pathway, reaching central nervous system tissue within minutes. The literature identifies its primary proposed mechanism as upregulation of brain-derived neurotrophic factor (BDNF), alongside nerve growth factor (NGF), vascular endothelial growth factor (VEGF), and modulation of dopaminergic and serotonergic signaling.

Chemical & Molecular Properties

FormulaC37H51N9O10S
Mol. Weight813.9 g/mol
PubChem CID9811102

Key Areas of Research Interest

  • Investigated in the context of neurotrophic factor regulation, including BDNF, NGF, and VEGF expression.
  • Investigated in the context of dopaminergic and serotonergic signaling modulation.
  • Investigated in the context of central nervous system delivery via the olfactory/intranasal pathway.
  • Investigated in the context of ACTH(4-10)-derived peptide structure-activity relationships.

FAQ

What is Semax commonly researched for?

In the research literature, Semax is studied mainly in connection with neurotrophic factor regulation (BDNF, NGF, VEGF) and dopaminergic/serotonergic signaling pathways, drawing on 229 indexed PubMed records. It is intended for laboratory research use only.

Is Semax FDA-approved?

No. Sold for laboratory research use only, not FDA-approved, not for human or veterinary consumption.

How is Semax stored?

Lyophilized and frozen, protected from light; refrigerated after reconstitution for research use.

What purity standard does Legendary Labz hold Semax to?

Every lot of Semax is third-party tested; the current lot (LL-4383620-P) verified at 99.34% purity.

Is a Certificate of Analysis available for Semax?

Yes. A Certificate of Analysis is published for Semax per lot, covering both purity and endotoxin testing.

Materials referenced on this page are intended for laboratory research purposes. No claims regarding therapeutic efficacy are made or implied. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.

Description

Overview

Semax is a synthetic heptapeptide derived from ACTH, developed in Russia in the 1980s and widely used there as a prescription nootropic. It dramatically upregulates BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor), the proteins responsible for neuronal growth, synaptic plasticity, and memory consolidation. Unlike stimulants, Semax doesn't cause crashes or dependency. It modulates dopamine and serotonin systems while reducing oxidative stress in neural tissue.

Structure & Chemistry

  • Molecular formula: C₃₇H₅₁N₉O₁₀S
  • Category: COGNITIVE / NEUROPROTECTIVE
  • Molecular size: 863.0 Da (Synthetic ACTH 4-10 heptapeptide analog)

Regulatory & Research Status

  • FDA: Not approved. Prescription nootropic in Russia (Semax nasal spray). No US IND or clinical trial registration.
  • WADA: Not currently prohibited, no performance enhancement classification.
  • Evidence: Russian clinical trials for ischemic stroke and cognitive decline. Western research is largely absent. Benefits in healthy users are extrapolated from clinical and animal data.

Specifications

Presentation 5mg or 10mg lyophilized peptide, single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category COGNITIVE / NEUROPROTECTIVE
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

Additional information

Size

5mg, 10mg

Certificates of Analysis

Independently tested by Horizon Analytical. Tap to open the full report.

🧪Purity Report
99.34% · Lot LL-4383620-POPEN ↗🛡Endotoxin Report
Lot LL-4383620-EOPEN ↗

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Overview

Semax is a synthetic heptapeptide derived from ACTH, developed in Russia in the 1980s and widely used there as a prescription nootropic. It dramatically upregulates BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor), the proteins responsible for neuronal growth, synaptic plasticity, and memory consolidation. Unlike stimulants, Semax doesn't cause crashes or dependency. It modulates dopamine and serotonin systems while reducing oxidative stress in neural tissue.

Structure & Chemistry

  • Molecular formula: C₃₇H₅₁N₉O₁₀S
  • Category: COGNITIVE / NEUROPROTECTIVE
  • Molecular size: 863.0 Da (Synthetic ACTH 4-10 heptapeptide analog)

Regulatory & Research Status

  • FDA: Not approved. Prescription nootropic in Russia (Semax nasal spray). No US IND or clinical trial registration.
  • WADA: Not currently prohibited, no performance enhancement classification.
  • Evidence: Russian clinical trials for ischemic stroke and cognitive decline. Western research is largely absent. Benefits in healthy users are extrapolated from clinical and animal data.

Specifications

Presentation 5mg or 10mg lyophilized peptide, single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category COGNITIVE / NEUROPROTECTIVE
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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