Description
Overview
MOTS-c is a mitochondria-derived peptide (MDP), encoded within the mitochondrial genome rather than the nuclear genome, making it unique among peptides. It acts as an exercise mimetic by activating AMPK (AMP-activated protein kinase), the master metabolic switch that mimics the cellular effects of physical exercise. MOTS-c regulates glucose metabolism, promotes fatty acid oxidation, and suppresses de novo lipogenesis.
Structure & Chemistry
- Molecular formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Category: METABOLIC / EXERCISE MIMETIC
- Molecular size: 2,174.5 Da (16-amino-acid mitochondrial-derived peptide)
Regulatory & Research Status
- FDA: Not approved. Research compound. No IND pathway established for human therapeutic use.
- WADA: Not currently listed as prohibited.
- Evidence: Primarily mouse and cellular data (Kim et al. Cell Metabolism 2015 landmark paper). Human studies beginning to emerge but no clinical trials completed.
Specifications
| Presentation | 10mg single vial |
|---|---|
| Purity | >99% by HPLC |
| Form | Lyophilized powder (reconstitute with bacteriostatic water for laboratory use) |
| Category | METABOLIC / EXERCISE MIMETIC |
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.
Reviews
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