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KPV — 10mg

Tripeptide / Alpha-MSH C-Terminal Fragment

KPV is a bioidentical tripeptide corresponding to a fragment of endogenous alpha-MSH, with 109 indexed PubMed records (42 human, 95 animal) forming its research literature.

$25.00

KPV (Lys-Pro-Val) is a naturally occurring tripeptide, the C-terminal fragment of alpha-MSH (alpha-melanocyte stimulating hormone). It’s bioidentical, produced endogenously as an anti-inflammatory regulator. KPV directly inhibits

SKU: LL-KPV-10 Category:

PubMed Literature Index

109

studies indexed in the public literature

Q2 2026 · view PubMed search ↗

42
Human
95
Animal
0
Clinical Trials
0
EU Trials

Overview

In the literature, KPV is described as the C-terminal fragment of endogenous alpha-MSH, structurally linking it to the melanocortin system. Studies describe its primary proposed mechanism as engagement of melanocortin receptors, alongside a separately reported pathway involving direct suppression of NF-kB signaling that does not depend on receptor binding. Research on oral delivery has also focused on the PepT1 transporter, which studies describe as upregulated in inflamed gastrointestinal tissue, a pattern investigators note could make gut-localized transport tissue-selective.

Chemical & Molecular Properties

FormulaC16H30N4O4
Mol. Weight342.43 g/mol
PubChem CID125672

Key Areas of Research Interest

  • Investigated in the context of melanocortin receptor signaling
  • Investigated in the context of NF-kB pathway regulation
  • Investigated in the context of PepT1-mediated gastrointestinal transport
  • Investigated in the context of inflamed gastrointestinal (IBD-model) tissue

FAQ

What is KPV commonly researched for?

In the research literature, KPV is examined for its proposed roles in melanocortin receptor signaling and NF-kB pathway regulation, including studies of PepT1-mediated transport in inflamed gastrointestinal tissue. It is sold strictly for laboratory research use, not for human or animal use.

Is KPV FDA-approved?

No. Sold for laboratory research use only, not FDA-approved, not for human or veterinary consumption.

How is KPV stored?

Lyophilized and frozen, protected from light; refrigerated after reconstitution for research use.

What purity standard does Legendary Labz hold KPV to?

Every lot of KPV is third-party tested to verify purity and identity before release for research use.

Is a Certificate of Analysis available for KPV?

Yes. Certificates of Analysis are published per lot as testing completes.

Materials referenced on this page are intended for laboratory research purposes. No claims regarding therapeutic efficacy are made or implied. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.

Description

Overview

KPV (Lys-Pro-Val) is a naturally occurring tripeptide, the C-terminal fragment of alpha-MSH (alpha-melanocyte stimulating hormone). It's bioidentical, produced endogenously as an anti-inflammatory regulator. KPV directly inhibits NF-κB, reducing IL-1, IL-6, and TNF-alpha. Its mechanism is well-characterized in human intestinal cell lines: it enters inflamed gut epithelium via the PepT1 transporter (which is upregulated in IBD), making oral delivery especially targeted in colitis. Preclinical models consistently show colitis improvement. Human RCTs have not been conducted. Unlike many peptides, KPV does not cause melanogenic (tanning) effects due to lacking the N-terminal α-MSH sequence.

Structure & Chemistry

  • Molecular formula: C₁₆H₃₀N₄O₄
  • Category: ANTI-INFLAMMATORY / GUT HEALING
  • Molecular size: 342.43 Da (Lys-Pro-Val tripeptide)

Regulatory & Research Status

  • NO HUMAN CLINICAL TRIALS: All IBD and skin benefits are from animal models and human cell studies (in vitro); no published human RCTs.
  • FDA: Not approved for any indication; available through research/compounding channels.
  • BIOIDENTICAL: KPV is the C-terminal tripeptide of endogenous α-MSH, strong mechanistic rationale for safety.
  • DOSING: Practitioner-derived protocols only; no clinical dose-finding studies in humans.
  • CANCER NOTE: KPV shows antitumorigenic potential in colitis-associated cancer mouse models via PepT1 pathway, no human data.

Specifications

Presentation 10mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category ANTI-INFLAMMATORY / GUT HEALING
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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Overview

KPV (Lys-Pro-Val) is a naturally occurring tripeptide, the C-terminal fragment of alpha-MSH (alpha-melanocyte stimulating hormone). It's bioidentical, produced endogenously as an anti-inflammatory regulator. KPV directly inhibits NF-κB, reducing IL-1, IL-6, and TNF-alpha. Its mechanism is well-characterized in human intestinal cell lines: it enters inflamed gut epithelium via the PepT1 transporter (which is upregulated in IBD), making oral delivery especially targeted in colitis. Preclinical models consistently show colitis improvement. Human RCTs have not been conducted. Unlike many peptides, KPV does not cause melanogenic (tanning) effects due to lacking the N-terminal α-MSH sequence.

Structure & Chemistry

  • Molecular formula: C₁₆H₃₀N₄O₄
  • Category: ANTI-INFLAMMATORY / GUT HEALING
  • Molecular size: 342.43 Da (Lys-Pro-Val tripeptide)

Regulatory & Research Status

  • NO HUMAN CLINICAL TRIALS: All IBD and skin benefits are from animal models and human cell studies (in vitro); no published human RCTs.
  • FDA: Not approved for any indication; available through research/compounding channels.
  • BIOIDENTICAL: KPV is the C-terminal tripeptide of endogenous α-MSH, strong mechanistic rationale for safety.
  • DOSING: Practitioner-derived protocols only; no clinical dose-finding studies in humans.
  • CANCER NOTE: KPV shows antitumorigenic potential in colitis-associated cancer mouse models via PepT1 pathway, no human data.

Specifications

Presentation 10mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category ANTI-INFLAMMATORY / GUT HEALING
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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