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PT-141 — 10mg

Cyclic Heptapeptide / Alpha-MSH Analog

PT-141 is a cyclic heptapeptide analog of alpha-MSH, represented in the indexed research literature by 119 PubMed records, including 4 clinical studies.

$25.00

PT-141 (Bremelanotide) is a melanocortin receptor agonist, specifically MC3R and MC4R, that works centrally in the brain rather than through vascular mechanisms like PDE5 inhibitors (Viagra).

SKU: LL-PT141-10 Category:

PubMed Literature Index

119

studies indexed in the public literature

Q2 2026 · view PubMed search ↗

88
Human
95
Animal
4
Clinical Trials
0
EU Trials

Overview

Studies describe PT-141 (Bremelanotide) as a cyclic heptapeptide analog of alpha-MSH capable of crossing the blood-brain barrier to activate melanocortin receptors MC3R and MC4R in the hypothalamus. The literature contrasts this proposed central mechanism with PDE5 inhibitors, which are described as acting peripherally on vasculature rather than through central nervous system receptor pathways. The compound is also documented in the literature as the active ingredient in the FDA-approved intranasal product Vyleesi, indicated for hypoactive sexual desire disorder (HSDD) in premenopausal women.

Chemical & Molecular Properties

FormulaC50H68N14O10
Mol. Weight1025.2 g/mol
PubChem CID9941379

Key Areas of Research Interest

  • Investigated in the context of melanocortin receptor (MC3R/MC4R) pharmacology
  • Investigated in the context of central nervous system and hypothalamic signaling pathways
  • Investigated in the context of blood-brain barrier permeability of cyclic peptide analogs
  • Investigated in the context of hypoactive sexual desire disorder (HSDD) research literature
  • Investigated in the context of comparisons between centrally-acting and peripherally-acting (e.g., PDE5 inhibitor) compounds

FAQ

What is PT-141 commonly researched for?

Research involving PT-141 is documented in the literature in relation to melanocortin receptor (MC3R/MC4R) pharmacology, central nervous system and hypothalamic signaling, and hypoactive sexual desire disorder (HSDD), reflected across 119 indexed PubMed records including 4 clinical studies.

Is PT-141 FDA-approved?

No. Sold for laboratory research use only, not FDA-approved, not for human or veterinary consumption.

How is PT-141 stored?

Supplied lyophilized and frozen, protected from light; refrigerated after reconstitution for research use.

What purity standard does Legendary Labz hold PT-141 to?

Every lot of PT-141 is independently, third-party tested to verify purity and identity before release for research use.

Is a Certificate of Analysis available for PT-141?

COAs are published per lot as testing completes; contact Legendary Labz for the current lot's Certificate of Analysis for PT-141.

Materials referenced on this page are intended for laboratory research purposes. No claims regarding therapeutic efficacy are made or implied. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.

Description

Overview

PT-141 (Bremelanotide) is a melanocortin receptor agonist, specifically MC3R and MC4R, that works centrally in the brain rather than through vascular mechanisms like PDE5 inhibitors (Viagra). This means it activates desire and arousal at the neurological level, working for both men and women. Originally developed from a sunless tanning peptide (MT-II), researchers noted powerful sexual side effects, which led to dedicated development. FDA-approved as Vyleesi for female HSDD. It works within 30-60 minutes and effects last 8-12 hours.

Structure & Chemistry

  • Molecular formula: C₅₀H₆₈N₁₄O₁₀
  • Category: SEXUAL HEALTH / LIBIDO
  • Molecular size: 1,025.2 Da (Cyclic Heptapeptide)

Specifications

Presentation 10mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category SEXUAL HEALTH / LIBIDO
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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Overview

PT-141 (Bremelanotide) is a melanocortin receptor agonist, specifically MC3R and MC4R, that works centrally in the brain rather than through vascular mechanisms like PDE5 inhibitors (Viagra). This means it activates desire and arousal at the neurological level, working for both men and women. Originally developed from a sunless tanning peptide (MT-II), researchers noted powerful sexual side effects, which led to dedicated development. FDA-approved as Vyleesi for female HSDD. It works within 30-60 minutes and effects last 8-12 hours.

Structure & Chemistry

  • Molecular formula: C₅₀H₆₈N₁₄O₁₀
  • Category: SEXUAL HEALTH / LIBIDO
  • Molecular size: 1,025.2 Da (Cyclic Heptapeptide)

Specifications

Presentation 10mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category SEXUAL HEALTH / LIBIDO
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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