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NAD+ — 500mg

Dinucleotide Coenzyme / Cellular Metabolism

NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring coenzyme and metabolic cofactor present in every cell, carrying an extensive body of indexed research literature, over 84,000 PubMed records including more than 500 clinical studies.

$50.00

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, essential for over 500 enzymatic reactions including energy metabolism (ATP production), DNA damage repair

SKU: LL-NAD-500 Category:

PubMed Literature Index

84979

studies indexed in the public literature

Q2 2026 · view PubMed search ↗

27934
Human
56869
Animal
533
Clinical Trials
0
EU Trials

Overview

Studies describe NAD+ not as a receptor agonist but as a fundamental coenzyme, participating in over 500 enzymatic reactions across cellular metabolism. In the literature, it is characterized as the electron carrier linking glycolysis to the mitochondrial electron transport chain, and as the required substrate for sirtuin deacetylases (SIRT1-7) and PARP DNA repair enzymes. Research also describes an approximate 50% decline in NAD+ levels between ages 40 and 60, a decline that studies link mechanistically to mitochondrial dysfunction and impaired DNA repair processes associated with the aging phenotype.

Chemical & Molecular Properties

FormulaC21H27N7O14P2
Mol. Weight663.4 g/mol
PubChem CID5892

Key Areas of Research Interest

  • investigated in the context of cellular energy metabolism and the electron transport chain
  • investigated in the context of sirtuin (SIRT1-7) deacetylase activity
  • investigated in the context of PARP-mediated DNA repair pathways
  • investigated in the context of mitochondrial function
  • investigated in the context of age-related NAD+ decline and the aging phenotype

FAQ

What is NAD+ commonly researched for?

NAD+ is studied in the context of cellular energy metabolism, sirtuin and PARP enzyme activity, mitochondrial function, and age-related decline in NAD+ levels. It is sold for laboratory research use only.

Is NAD+ FDA-approved?

No. Sold for laboratory research use only, not FDA-approved, not for human or veterinary consumption.

How is NAD+ stored?

Lyophilized and frozen, protected from light; refrigerated after reconstitution for research use.

What purity standard does Legendary Labz hold NAD+ to?

Every lot of NAD+ is independently third-party tested to verify identity and purity before release for research use.

Is a Certificate of Analysis available for NAD+?

Certificates of Analysis are published per lot as testing completes.

Materials referenced on this page are intended for laboratory research purposes. No claims regarding therapeutic efficacy are made or implied. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.

Description

Overview

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, essential for over 500 enzymatic reactions including energy metabolism (ATP production), DNA damage repair via PARP enzymes, and sirtuins, the longevity proteins. NAD+ levels decline 50%+ from youth to middle age. IV or injectable NAD+ bypasses gut absorption limitations and delivers the coenzyme directly to cells. Effects include dramatic mental clarity, energy restoration, reduced addiction cravings, and cellular rejuvenation.

Structure & Chemistry

  • Molecular formula: C₂₁H₂₇N₇O₁₄P₂
  • Category: CELLULAR ENERGY / ANTI-AGING
  • Molecular size: 663.4 Da (Nicotinamide Adenine Dinucleotide)

Regulatory & Research Status

  • FDA: NAD+ is not an approved drug. IV and injectable NAD+ is widely used in clinical wellness settings. Not FDA-approved for any specific indication, but generally recognized as a dietary supplement precursor (NR, NMN) orally.
  • WADA: Not currently prohibited.
  • Evidence: Human trial data is limited, small studies support benefits in addiction recovery and cellular energy markers. Most cognitive and longevity claims extrapolate from preclinical data.

Specifications

Presentation 500mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category CELLULAR ENERGY / ANTI-AGING
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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Overview

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, essential for over 500 enzymatic reactions including energy metabolism (ATP production), DNA damage repair via PARP enzymes, and sirtuins, the longevity proteins. NAD+ levels decline 50%+ from youth to middle age. IV or injectable NAD+ bypasses gut absorption limitations and delivers the coenzyme directly to cells. Effects include dramatic mental clarity, energy restoration, reduced addiction cravings, and cellular rejuvenation.

Structure & Chemistry

  • Molecular formula: C₂₁H₂₇N₇O₁₄P₂
  • Category: CELLULAR ENERGY / ANTI-AGING
  • Molecular size: 663.4 Da (Nicotinamide Adenine Dinucleotide)

Regulatory & Research Status

  • FDA: NAD+ is not an approved drug. IV and injectable NAD+ is widely used in clinical wellness settings. Not FDA-approved for any specific indication, but generally recognized as a dietary supplement precursor (NR, NMN) orally.
  • WADA: Not currently prohibited.
  • Evidence: Human trial data is limited, small studies support benefits in addiction recovery and cellular energy markers. Most cognitive and longevity claims extrapolate from preclinical data.

Specifications

Presentation 500mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category CELLULAR ENERGY / ANTI-AGING
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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