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MOTS-c — 10mg

Mitochondrial-Derived Peptide / 12S rRNA Origin

MOTS-C is a 16-amino acid mitochondrial-derived peptide encoded within the mitochondrial genome, and it carries a growing body of indexed PubMed research spanning human and animal studies.

$30.00

MOTS-c is a mitochondria-derived peptide (MDP), encoded within the mitochondrial genome rather than the nuclear genome, making it unique among peptides. It acts as an exercise

Certificates of Analysis

Independently tested by Horizon Analytical. Tap to open the full report.

🧪Purity Report
99.31% · Lot LL-4825741-POPEN ↗🛡Endotoxin Report
Lot LL-4825741-EOPEN ↗
SKU: LL-MOTSC-10 Category:

PubMed Literature Index

249

studies indexed in the public literature

Q2 2026 · view PubMed search ↗

137
Human
190
Animal
8
Clinical Trials
0
EU Trials

Overview

Studies describe MOTS-C as a peptide encoded within the mitochondrial genome, specifically the 12S rRNA gene, and identify it as the first mitochondria-derived peptide reported to function as a systemic signaling molecule. In the literature, MOTS-C is described as being released from mitochondria under conditions of metabolic stress, after which it translocates to the nucleus. Research characterizes this translocation as coinciding with activation of AMPK signaling and the antioxidant response element (ARE) gene program, pathways studied in connection with mitochondrial function, insulin signaling, and cellular stress response.

Chemical & Molecular Properties

FormulaC101H152N28O22S2
Mol. Weight2174.6 g/mol
PubChem CID146675088

Key Areas of Research Interest

  • Investigated in the context of mitochondrial-derived peptide (MDP) signaling and mitochondrial genome-encoded regulation
  • Investigated in the context of AMPK pathway activation and cellular energy regulation
  • Investigated in the context of the antioxidant response element (ARE) gene program
  • Investigated in the context of insulin sensitivity and metabolic stress response
  • Investigated in the context of exercise-associated signaling processes

FAQ

What is MOTS-C commonly researched for?

MOTS-C is studied in the research literature for its proposed role as a mitochondria-derived peptide involved in AMPK activation, the antioxidant response element (ARE) gene program, and metabolic stress signaling. It is sold strictly for laboratory research use.

Is MOTS-C FDA-approved?

No. Sold for laboratory research use only, not FDA-approved, not for human or veterinary consumption.

How is MOTS-C stored?

Lyophilized and frozen, protected from light; refrigerated after reconstitution for research use.

What purity standard does Legendary Labz hold MOTS-C to?

Legendary Labz tests every lot of MOTS-C through third-party laboratories for purity and endotoxin content, with results documented under lot-specific Certificate of Analysis references (purity report LL-4825741-P).

Is a Certificate of Analysis available for MOTS-C?

Yes. A Certificate of Analysis is published for MOTS-C, documenting third-party purity and endotoxin testing per lot.

Materials referenced on this page are intended for laboratory research purposes. No claims regarding therapeutic efficacy are made or implied. Not for human or veterinary use. Not evaluated by the FDA. Must be 21+.

Description

Overview

MOTS-c is a mitochondria-derived peptide (MDP), encoded within the mitochondrial genome rather than the nuclear genome, making it unique among peptides. It acts as an exercise mimetic by activating AMPK (AMP-activated protein kinase), the master metabolic switch that mimics the cellular effects of physical exercise. MOTS-c regulates glucose metabolism, promotes fatty acid oxidation, and suppresses de novo lipogenesis.

Structure & Chemistry

  • Molecular formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
  • Category: METABOLIC / EXERCISE MIMETIC
  • Molecular size: 2,174.5 Da (16-amino-acid mitochondrial-derived peptide)

Regulatory & Research Status

  • FDA: Not approved. Research compound. No IND pathway established for human therapeutic use.
  • WADA: Not currently listed as prohibited.
  • Evidence: Primarily mouse and cellular data (Kim et al. Cell Metabolism 2015 landmark paper). Human studies beginning to emerge but no clinical trials completed.

Specifications

Presentation 10mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category METABOLIC / EXERCISE MIMETIC
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

Certificates of Analysis

Independently tested by Horizon Analytical. Tap to open the full report.

🧪Purity Report
99.31% · Lot LL-4825741-POPEN ↗🛡Endotoxin Report
Lot LL-4825741-EOPEN ↗

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Overview

MOTS-c is a mitochondria-derived peptide (MDP), encoded within the mitochondrial genome rather than the nuclear genome, making it unique among peptides. It acts as an exercise mimetic by activating AMPK (AMP-activated protein kinase), the master metabolic switch that mimics the cellular effects of physical exercise. MOTS-c regulates glucose metabolism, promotes fatty acid oxidation, and suppresses de novo lipogenesis.

Structure & Chemistry

  • Molecular formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
  • Category: METABOLIC / EXERCISE MIMETIC
  • Molecular size: 2,174.5 Da (16-amino-acid mitochondrial-derived peptide)

Regulatory & Research Status

  • FDA: Not approved. Research compound. No IND pathway established for human therapeutic use.
  • WADA: Not currently listed as prohibited.
  • Evidence: Primarily mouse and cellular data (Kim et al. Cell Metabolism 2015 landmark paper). Human studies beginning to emerge but no clinical trials completed.

Specifications

Presentation 10mg single vial
Purity >99% by HPLC
Form Lyophilized powder (reconstitute with bacteriostatic water for laboratory use)
Category METABOLIC / EXERCISE MIMETIC
For laboratory and research use only. Not for human or animal consumption. Not approved by the FDA for any therapeutic use. No claims regarding therapeutic efficacy are made or implied. Must be 21 or older.

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