Description
Overview
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide, a chain of 15 amino acids derived from a protective protein found naturally in human gastric juice. In preclinical research it has been studied for its effects on tissue repair, angiogenesis, and modulation of nitric-oxide signaling, appearing to act locally with a systemic amplification effect. Human data remains limited to small pilot studies (fewer than 30 participants across all studies); large-scale randomized controlled trials have not been completed.
Research Findings
Areas examined in the preclinical literature include:
- Acceleration of tendon, ligament, and muscle healing in animal models, with limited human pilot data.
- Repair of gut lining, including small pilot data in interstitial cystitis.
- Anti-inflammatory activity via nitric-oxide and VEGF pathways.
- Neuroprotective effects supporting CNS and peripheral nerve recovery in animal models.
- Bone density and joint-integrity improvements in animal models.
Structure & Chemistry
- Class: Pentadecapeptide (15-amino-acid sequence)
- Molecular formula: C₆₂H₉₈N₁₆O₂₂
- Molecular weight: 1419.53 g/mol
- Approximate size: ~1.8 kDa
- Solubility: Water-soluble; stable in solution (slightly acidic, pH ~5–6)
Regulatory & Research Status
- FDA Category 2 (2023): cannot be legally compounded in the US for commercial use.
- WADA Prohibited (2022): listed under S0 Non-Approved Substances.
- Human evidence is limited to small pilot studies; no completed Phase 2/3 RCTs.
- Findings above are drawn primarily from animal and in-vitro studies. Human clinical confirmation is pending.
Specifications
| Presentation | 10 mg lyophilized peptide, single vial |
|---|---|
| Purity | >99% by HPLC |
| Form | Lyophilized powder (reconstitute with bacteriostatic water for laboratory use) |
| Category | Systemic repair / GI research |

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